Crystal Structure Determination

Leveraging high-resolution X-ray crystallography, we drive forward the realm of structural biology study and drug discovery. Our proficiency lies in unraveling intricate three-dimensional structures of biomolecules to study biological function and aid in drug development. These structures serve as essential blueprints, enabling our clients to make informed decisions towards project success. Atomic-level insights offered by crystal structures serve as a formidable tool in the hands of chemists, accelerating the optimization of leads with precision and accuracy.

In the intricate landscape of drug discovery, our dedication to providing reliable, detailed structural data stands as a cornerstone. By shedding light on the molecular intricacies, we empower our clients to navigate this journey with heightened efficiency and confidence.

At Structure Based Design, we crystalize proteins using our high throughput nanoliter dispensing robot, saving time and making efficient use of precious samples. Crystals from coarse matrix screens are optimized using fine screens, additives, and seeding. Depending on the project we may perform co-crystallization with your compounds or crystalize the apo protein and soak your compounds in for data collection. We collect X-ray data on world-renowned synchrotron beamlines (SSRL or ALS), ensuring the highest resolution for your project. Our scientists solve your structure with molecular replacement or advanced de novo phasing techniques. Once solved, we prepare a detailed comparative analysis of your protein co-crystal structures.

Structure-based drug design (SBDD) can be used to optimize lead compound specificity and binding affinity, while enhancing efficacy, by eliminating unwanted physiochemical properties to yield more efficient candidates. Such strategies have the potential to shave off years and millions of dollars in the processes toward identification of a new drug candidate. SBD's structural biology experience and proprietary technology gives clients the power of structure-based design into their drug discovery program. Since our inception in 2007, we have solved hundred cocrystal structures for our clients and supported many SBDD compounds into clinical trials.

Beyond our crystal structure determination services, we extend a comprehensive array of structure analysis packages that infuse the prowess of rational design into your drug discovery journey. At SBD, we understand that true innovation in drug development lies not just in data collection, but in the skillful interpretation of that data.

Our team of experts delve into all accessible structures of your target, and through an engaging 3D molecular graphics presentation, we unravel vital interactions, spotlight conformational shifts catalyzed by inhibitors, and address your questions. This interactive discourse can transpire either face-to-face or through virtual conferences.

Our passion lies in helping our clients apply high-resolution structures to foster innovation. With SBD, it's not just about research, it's collaborative discovery and the shared journey toward impactful structural biology and drug development.